Side effects of gabapentin [Py4jbA26P]

Side effects of gabapentin [Py4jbA26P]

Anticonvulsant; first approved for treatment of partial seizures Later approved for treatment of neuropathic pain Binds and inhibits the alpha2-delta subunit of a voltage-gated calcium channel → decreased release of the excitatory neurotransmitter glutamate Glutamate is the primary neurotransmitter mediating afferent nociceptive transmission from the dorsal root ganglia to the spinal cord Signal transmission triggers NMDA glutamate receptor activity Today gabapentin has multiple uses: depression, anxiety, painful diabetic neuropathy, trigeminal neuralgia, and phantom-limb pain, part of multimodal analgesia approach in ERAS Common side effects include nausea sedation dizziness ataxia nystagmus peripheral edema weight gain abuse potential cardiac and respiratory: uncommon

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